List of Grand Theft Auto VI characters (Johnsonverse)

Playable

 * Joshua "Josh" Walton (Tim Johnson) is a 26-year-old aspiring bank robber based in Los Santos. It is also heavily implied throughout the game that his and Elise's childhoods were abusive. Special ability: bullet time.
 * Elise Walton (Chloe Johnson) is Josh's twin sister from Vice City, who is a mood-swinging psychopath more unhinged than Trevor Philips, to the point of bragging about having choked children to death in a fit of rage, and even willingly following Walker Carrington's request to blow up a children's hospital so he could make a quick buck on its prime real estate. Despite this, she loves her brother dearly, and will always be at his side until the end; Josh will also never be able to kill her, always saying comments such as "We're better than Cain and Abel", and vice-versa. Special ability: rage.
 * Christopher "Chris" Fallon (Christopher Boyer) is a 48-year-old former cop. He lives in Liberty City, and works for Roman Bellic's cab service, though he also deals drugs on the side to make extra cash. Special ability: perfect accuracy.
 * Taliana "Tallie" Martinez (Carolina Ravassa) is a 34-year-old former bank robber who, following the Union Depository job in 2013, now deals in boosting, modding, and reselling cars in San Fierro; this operation directly conflicts with Simeon's newest scam. She was a heist crew member in Grand Theft Auto V who proved popular enough to be promoted to playable. Special ability: slow down time while driving.
 * Walt Sanders (Ving Rhames) is a 51-year-old arms dealer from Carcer City, and the father of nine-year-old Alexis Sanders. His wife Leigh was killed in a gang war prior to the game's events, and he's out to avenge her by tracking its leader down to kill him. Special ability: dodging bullets.
 * Karissa Thorn (Kyla Pratt) is a 23-year-old member of the Grunge Girls from Las Venturas who is relatively new to the criminal lifestyle. Special ability: stronger kicks and punches.

Anguila, Marina and Atlántica (HD Universe Vice City)

 * Alejandro Ortiz (Antonio Sabato, Jr.) is a local criminal who has Elise do the dirty work for him.

Vice City Beach, Vice City Mainlands, Starfish Island, and Prawn Island (3D Universe Vice City)

 * Thomas "Tommy" Vercetti (Ray Liotta) is a 68-year-old washed-up crime boss seeking to recapture the glory days of the 1980s with the help of the Walton twins and Ken Rosenberg, although the latter does so reluctantly due to Tommy cutting ties with him in 1992. He is playable in a few missions.
 * Stephen Winslow (Chris Pratt) is a 37-year-old local mechanic and a member of the reformed Vercetti Crime Family.
 * Peter "Pete" Vance (Armando Riesco) is the 56-year-old brother of Victor and Lance Vance who moved to Vice City in 1999. He is playable in a few missions.
 * Dee-Dee "Dee Generate" Garcia (Holly Fields) is the 59-year-old leader of the Royals of Vice.
 * Lazlow Jones (Lazlow Jones) is a 57-year-old fading celebrity who's forced to move to Vice City and host a local, low-budget game show called Win Some, Lose Some after Gay Tony fired him from his San Andreas nightclub. He is forced to partner with the Cartel to deal drugs like SPANK, crack, meth and cocaine to make money, which he gets high on himself.
 * Mary-Beth Williams (Scarlett Johansson) is the 35-year-old daughter of Louise Williams.
 * Raymond "Ray" Machowski (Peter Appel) is a 61-year-old former Liberty City cop who moved to Vice City to avoid internal affairs and the IAA, posing under the name Randall McKinney. Now the mayor, Ray's corruption hasn’t gone away, and he hires Elise to do the dirty work for him, such as slandering his political opponents to ensure he wins his reelection campaign. He is allied with the Corvino Crime Family.
 * Umberto Robina (Danny Trejo) is the 75-year-old leader of Los Cabrones, a Cuban gang.
 * Esther "Auntie Poulet" Plymouth (Youree Dell Cleomili Harris) is the 119-year-old leader of the Poison of the Tigers (Family of the Knives), a Haitian gang. She is killed by Tommy during the mission "Date D'Expiration du Poulet" after Ken reminds him of his time with the gang.
 * Reni Wassulmaier (Barbara Rosenblatt) is a 66-year-old transgender film director. She hires Elise to act in a film she's directing.
 * Isadore Papi (Toby Huss) is the 72-year-old Don of the Papi Crime Family.
 * Katelyn Papi (Serena Irwin) is Isadore's 60-year-old wife. She has a tendency to only wear a bra, skirt and shoes every day.
 * Wallace Papi (Oscar Issac) is Isadore's 24-year-old, rather spoiled son and eventual successor. He also serves as the family underboss.
 * Giorgio Ricci (Danny Mastrogiorgio) is the Caporegime of the family. He is rude to everyone outside the Papi family.
 * Madison "Muffy" Leech (Laura Bailey) is a 19-year-old punk musician who has Katelyn as her agent.
 * Issac Corvino (Tony Sirico) is the 78-year-old Don of the Corvino Crime Family.
 * Samantha Corvino (Alanna Ubach) is Issac's 30-year-old, recently married wife and a well-known local singer. She is loyal to Issac.
 * Donny Corvino (Gary Nelson) is Issac's 29-year-old son, eventual successor, and the Underboss of the family. He is very short-tempered.
 * Dino Bianchi (Rick Corso) is the Caporegime of the Corvino family.
 * Sergio Romano (Joe Mantegna) is the 57-year-old Don of the Romano Crime Family.
 * Elsa Romano (Connie Stevens) is Sergio's 52-year-old wife.
 * Mateo Romano (Jon Favreau) is Sergio and Elsa's 24-year-old son and the family Underboss.
 * Margaret Wayne (Betty White) is a 92-year-old former nun who, in 1955, founded the Mothers Against the Glorification of the Gross and Offensive Trading of Sins (M.A.G.G.O.T.S.), a group that supports the illegalization of the sale of rock albums, violent video games and movies to minors, whom M.A.G.G.O.T.S. sees as "impressionable". She is killed by Taliana by exploding in her car during the mission "You Wouldn’t Steal A Car" after she discovers Margaret has been pirating movies and doctoring them to further her agenda (for example, editing footage of naked women into Meltdown when there wasn't any nudity to begin with, which causes Michael to give the order to kill her for disrespecting Solomon Richards' legacy).
 * Jasmond Raston (Haley Lu Richardson) is a 20-year-old ditzy model.
 * Jeffrey Tambor (himself) is a celebrity who's visiting Vice City. His agent hires Elise to be his bodyguard and take out anyone who wants to enact vigilante justice over the real-life sexual assualt allegations against Tambor.
 * Phil Collins (himself) is another celebrity visiting Vice City. His agent hires Josh to be his bodyguard.
 * Candice Shand (Jenna Jameson) is a 56-year-old former porn star and an entrepreneur. She owns the InterGlobal Films studio that Tommy lost in the 1990s.
 * Stephen "Steve" Scott
 * Mitchell "Mitch" Baker
 * Alexander "Alex" Shrub (Christopher Lucas) is a 58-year-old former congressman who was a Presidential candidate in 2000. He still hasn't gotten over his cross-dressing hobby, and is killed by Elise in the mission "The Fall of Martha".
 * Hilary King (Charley Tucker) is a man with a eating disorder who was killed in 1986. He is only seen briefly in the prologue and in flashbacks.

Los Santos

 * Michael De Santa (Ned Luke) is a 51-year-old Vinewood movie producer and former bank robber. He is playable in a few missions.
 * Jimmy De Santa (Danny Tamberelli) is Michael's 26-year-old son who works at the Videogeddon arcade in Los Santos.
 * Tracey De Santa (Michal Sinnott) is Michael's 28-year-old daughter who recently graduated college and is currently a nursing student.
 * Amanda De Santa (Vicki Van Tassel) is Michael's 49-year-old wife who is now a high-ranking executive at Fruit Computers (mainly thanks to Lester getting dirt on higher-ranking executives to move her up the ladder).
 * Franklin Clinton (Shawn "Solo" Fonteno) is the 31-year-old leader of the Grove Street Families, which retook Grove Street from the Ballas a month before the game's events. He moved back to Los Santos in 2016, and is playable in a few missions.
 * Denise Clinton (Janet Hubert) is Franklin's 63-year-old maternal aunt who is a feminist. She likes to do spirit walks with her friends. Trevor kills her and her friends during a spirit walk in the mission "We Are Women, and We Are Free!" for being so horrible and ungrateful to Franklin.
 * Lamar Davis (Gerald "Slink" Johnson) is Franklin's 31-year-old best friend and second-in-command of the Grove Street Families.
 * Simeon Yetarian (Demosthenes Chrysan) is a 52-year-old egotistical Armenian car salesman.
 * Wendy Oates (Kate Locklain) is Franklin's 23-year-old girlfriend.
 * Anthony "Gay Tony" Prince (David "D.B. Cooper" Kenner) is the 53-year-old owner of a Los Santos nightclub.
 * Carl "CJ" Johnson (Chris Bellard a.k.a. Young Maylay) is a 51-year-old former Grove Street Families OG turned rapper who owns a stake in the Four Dragons Casino. CJ finds himself back in the 'hood when he hears C.R.A.S.H. has been reformed under Irving Tenpenny. He is playable in a few missions.
 * Denise Johnson (Heather Alicia Simms) is CJ's 50-year-old wife. She owns a chain of beauty shops called Denise Does It.
 * Sean "Sweet" Johnson (Faizon Love) is a 54-year-old former Grove Street Families OG who became an actor, and like his brother CJ, found himself back in the 'hood after the resurrection of C.R.A.S.H.
 * Kendl Johnson (Yolanda "Yo-Yo" Whittaker) is CJ and Sweet's 49-year-old sister and Cesar’s wife. She is now a model, and, again, finds herself back in the 'hood after C.R.A.S.H.'s return.
 * Lance "Ryder" Wilson (Aaron "MC Eiht" Tyler) is a 52-year-old former Families OG. He is now an arms dealer who is still as snarky as ever. Once believed to have betrayed the Grove and sided with the Ballas, in truth, he was actually a mole working for CJ, the two of them having faked Ryder's death to throw Tenpenny off his tail; he resurfaced shortly after Tenpenny's death (Cesar's remark about Ryder trying to rape Kendl was an attempt to make CJ feel better after the latter was supposedly mortified, while the "killing" was staged by having CJ's gun shoot blanks instead of real bullets and some fake blood on Ryder's clothes). He replaced Emmet as the Los Santos arms dealer, offering newer hardware to the protagonists.
 * Kenneth “Ken” Rosenberg (William Fichtner) is a 66-year-old former lawyer and Tommy Vercetti’s former associate.
 * Matthew “Madd Dogg” Carlton (Ice-T) is a 55-year-old former rapper who now works as a talent agent.
 * ”Kent” Paul Higgins (Danny Dyer) is CJ's 54-year-old manager from England. He
 * Maurice "Maccer" Mooneyham (Shaun Ryder) is a 54-year-old singer who is attempting to recapture his glory of the 1980s and early 1990s. He is still a chronic masturbator.
 * Barry "Big Bear" Thorne (Kurt Alexander) is a 58-year-old former Families OG turned owner of Caligula's Casino. He is playable in a few missions.
 * Irving Tenpenny (Donald Glover) is a 34-year-old corrupt police officer and the leader of the revived C.R.A.S.H. He is the son of the deceased Frank Tenpenny, and is even worse than his father ever was, to the point of killing innocent people on the streets for kicks and teaming up with the Ballas, Vagos, and Rifa to make and distribute SPANK all around the country. He is the secondary antagonist of the game, answering directly to President Donald Love.
 * Beto Alvarez (Erik Estrada) is Tenpenny's 57-year-old associate. He was an honest cop until he was coerced by Tenpenny to join C.R.A.S.H. He makes it clear that he wants no part of the operation whatsoever.
 * Karen Daniels (Rebecca Henderson) is a 48-year-old corrupt IAA interrogator. She is killed by Niko with a bullet to the head in the mission "So Long, Michelle" as revenge for using him, though Niko tried to hold back tears upon succeeding.
 * Patrick “Packie” McReary (Ryan Johnston) is a 40-year-old bank robber formerly associated with Niko Bellic.
 * Lester Crest (Jay Klaitz) is a 52-year-old, physically-disabled evil genius who helps put together heists and operations.
 * Fabien LaRouche (Michael Giese) is a 45-year-old French yoga instructor. He is killed by Michael for attempting to hit on Amanda again in the mission "Nobody Said Yoga".
 * Brucie Kibbutz (Timothy Adams) is a 51-year-old fitness enthusiast and lifestyle coach who vehemently denies being gay, despite evidence pointing to the contrary.
 * Emmet Long (Eugene Jeter Jr.) is a 78-year-old, Families-associated gun dealer who moved to San Fierro in 2004 and opened a licensed gun shop there, though he's still associated with the gang.
 * Stephen "Steve" Scott (Dennis Hopper) is a film director.
 * Solomon Richards (Joel Rooks) is a film director.
 * Amy Walton (Rachel Weisz) is Josh and Elise's neglectful stepmother. She is killed by Elise during the mission "My Stepmother, the Car" for neglecting both her and Josh; Elise takes her car to the crusher with Amy in the trunk.
 * Brian Johnson (Terrell Ransom Jr.) was CJ, Sweet, and Kendl's younger brother. He was killed in 1987 at the age of 13, and only appears in flashbacks.
 * Beverly Johnson (Diahann Carroll) was Sweet, CJ, Kendl, and Brian's mother. She was killed in 1992 at the age of 51 after a Ballas ambush, and only appears in flashbacks. This was Carroll's final role before her 2019 death; Carroll was one of many dedications in the credits.
 * Melvin "Big Smoke" Harris (Clifton Powell) was a Grove Street Families OG who was killed in 1992 at the age of 27 after he, alongside Ryder, betrayed the gang for the Ballas and C.R.A.S.H. He only appears in flashbacks.
 * Franklin "Frank" Tenpenny (Samuel L. Jackson) was the leader of the original C.R.A.S.H. before he was killed in 1992 at the age of 46. He only appears in flashbacks.

Red County

 * Jeffrey "MC Strap" Cross (Jonathan Anderson) is a 47-year-old disgraced former rapper who had a resurgence under his new nickname, "MC Strap" (after his old nickname, "OG Loc", became associated with horrible rapping), from 1994 to 2017, when he was brought down in a sexual assault scandal (a jab at the real-life Bill Cosby sexual assault allegations); his vocals in his new rap songs were digitally manipulated to make it sound like he's actually rapping. He is killed by Franklin in the mission "OG Joke" as revenge for abandoning the Grove Street Families in 1992.

Blaine County

 * Trevor Philips (Steven Ogg) is a 54-year-old psychotic drug dealer who lives in Sandy Shores. Having been a lifestyle coach and guru in 2017, Trevor went back to his old self after Ron knocked him out and gave him smelling salts laced with crack. Trevor is also utterly terrified of Elise, which is saying something. He is playable in a few missions.
 * Ron Jakowski (David Mogentale) is Trevor's 44-year-old right-hand man.
 * Wade Hebert (Matthew Maher) is a 39-year-old loyal follower of Trevor who has been stuck in a strip club for six years.
 * Eric “Chef” Sizemore (Anthony Cumia) is

Las Venturas

 * Simon Sindacco (Joe Manganiello) is the 28-year-old Don of the Sindacco Crime Family. The Sindaccos moved out of Liberty City in 1999, settling permanently in Las Venturas.
 * Cyndi Lewis (Alexandra Daddario) is Karissa's 31-year-old best friend. She is a street punk and leader of the Venturas Gusanos, a gang that is instantly recognizable by having almost their entire bodies covered in tattoos, Cyndi included.
 * Julienne Holmes (Sunny Mabrey) is a 29-year-old member of the Grunge Girls and Karissa's rival.
 * Sondra Chen (Kelly Marie Tran) is Cyndi's 23-year-old second-in-command.
 * Celestia Bardas (Nicole Oliver) is the getaway driver for the Gusanos. Oliver was cast as an in-joke to her My Little Pony: Friendship is Magic character, Princess Celestia.
 * Claudia de Lance (Ashley Tisdale) is the gang’s tattoo artist. She owns a chain of tattoo shops called Claudia’s Needlz.
 * Liam Jennings (Hayden Christensen) is the muscle of the gang.
 * Amerie Emeria (Vanessa Parsons) is the owner of the Gusanos-affiliated Nightclub of Fortune, a brothel disguised as a nightclub, and the Gusanos' Madame, hiring prostitutes both male and female. She is seen only wearing a black snake bikini every day.
 * Thornton Duggan

San Fierro

 * Cesar Vialpando (Clifton Collins Jr.) is the 55-year-old leader of the Varrios Los Aztecas.
 * Mitch "The Truth" Wells (Peter Fonda) is a 90-year-old stoner hippie conspiracy theorist who has credible proof that the government is hiding aliens from the public. This was Fonda's final role before his death in August 2019, and the game was dedicated to his memory.
 * David "Zero" Kent (David Cross) is the 55-year-old owner of Zero RC, a hobby shop that is also a front for Carl Johnson's criminal enterprises. He is notably less annoying than he was in 1992, and even looks back at his annoyance with regret.
 * Ran Fa Li (Hunter Platin) is the 79-year-old leader of the Red Gecko Tong and the Shuk Foo of the San Fierro Triads. He only speaks in grunts, like in his previous appearance.
 * Wu Zi Mu (James Yaegashi) is the 54-year-old blind leader of the Mountain Cloud Boys and the Dai Dai Lo of the San Fierro Triads. He is part-owner of the Four Dragons Casino.
 * Bernie Crane (Timothy J. Alex) is a 41-year-old homosexual lifestyle coach. He mentions being attracted to Josh.

Broker, Dukes, Algonquin, and Bohan (HD Universe Liberty City)

 * Niko Bellic (Michael Hollick) is the 41-year-old, wheelchair-bound head of a major crime ring smuggling weapons to anti-Russian rebels in Ukraine. Having wanted to get out of crime, Niko is forced to get back in to help the rebels, and really, really hates bowling due to Roman constantly calling him to bowl at inappropriate times, culminating in Niko losing both of his legs after Roman called him to go bowling while the former was driving a truck that turned out to be rigged with explosives as a trap in 2016. He is playable in a few missions, in which he fights using a rocket launcher mounted to his wheelchair.
 * Roman Bellic (Jason Zumwalt) is the 42-year-old owner of two cab depots (one in Broker and one in Algonquin) and a professional bowler.
 * Mallorie Bellic (Elena Hurst) is Roman’s 40-year-old wife. She runs the cab depot when Roman is out bowling.
 * Kerry Bellic (Jackson Bollinger) is Roman and Mallorie's 11-year-old son, and Kate's older brother.
 * Kate Bellic (Skylar Dunn) is Roman and Mallorie's 10-year-old daughter. She was named after Niko's deceased girlfriend Kate McReary.
 * Milica Bellic (Diane Keaton) is Niko's 65-year-old mother and Kate's grandmother. She is depicted as caring.
 * "Little" Jacob Hughes (Coolie Ranx) is Niko's 37-year-old best friend and second-in-command.
 * Luis Fernando Lopez (Mario D'Leon) is the 36-year-old owner of Gay Tony's old nightclub. He is playable in a few missions.
 * Huang Lee (Steven Yeun) is the 36-year-old charismatic leader of the Liberty City Triads. He is playable in a few missions.
 * Malcolm "Malc" Kenley (Walter Mudu) is the 39-year-old leader of the Uptown Bikers.
 * Kenny Petrovic (Richard Pruitt) is the 63-year-old leader of the Petrovic Crime Family.
 * Lola Del Rio (Katie Semine) is a 38-year-old, lollipop-holding prostitute. She was heavily advertised in Grand Theft Auto IV, but never appeared in that game.
 * Christian "El Burro" Estevez (Jeff Garcia) is a 32-year-old Bohan drug dealer. He doesn't like being confused with El Burro, leader of the Diablos, and has even made several attempts on his life.
 * Elisabeth "Ellie" Dyer (Belle Armstrong) is a 24-year-old gaming enthusiast. She becomes Josh's girlfriend during the story.
 * Kristen Stewart (herself) is a celebrity visiting Liberty City. Her agent hires Karissa to be her bodyguard and take out crazed fans during a public appearance and autograph session.

Portland, Staunton Island, Shoreside Vale, and Chrisensen (3D Universe Liberty City)

 * Claude Speed (Scott Maslen) is a 48-year-old mute drifter who happened to come back to Liberty City years after Catalina's betrayal. He is playable in a few missions.
 * Maria Latore (Debi Mazar) is Claude's 48-year-old wife and the widow of the deceased mob boss Salvatore Leone. Formerly known as Maria La Torra, she changed her name to Latore upon returning from Las Venturas to Liberty City in 1992, having had a criminal record of her own. The gunshot at the end of III was actually Claude firing his pistol in the air to shut Maria up.
 * Florence St. John (Gia Carides) is a 20-year-old sarcastic street criminal who helps her boyfriend Rob carry out his plans.
 * Michael "Mike" Del Monte (Kirk Thornton) is a 45-year-old former Leone member who became bitter and hardened in the years since his longtime mentor Vinnie betrayed him, forcing him to come back to Liberty City to take his frustrations out on the city. He is playable in a few missions.
 * Walker Carrington (Johnny Hardwick) is the 44-year-old son of deceased real estate mogul Avery Carrington. Like his father, he’ll do anything to get prime real estate, including starting gang wars.
 * Antonio "Toni" Cipriani (Michael Madsen) is the 51-year-old, short-tempered Don of the Leone Crime Family. He became the Don of the Leone family after Salvatore's death, as his will stated that Toni be the Don; Toni decided to keep the Leone name in his honor. He is playable in a few missions.
 * Emily Cipriani (Jennifer Missoni) is Toni’s 35-year-old wife.
 * Rafaello Cipriani (Max Charles) is Toni's 16-year-old son.
 * Victoria “Tori” Cipriani (Millie Bobby Brown) is Rafaello’s twin sister. She is
 * Joey Leone (Michael Rapaport) is the 51-year-old son of Salvatore Leone, and the Underboss of the Leone Crime Family after his father's death.
 * Misty Wallis (Kim Gurney) is Joey's 37-year-old wife and a former prostitute. In the years since Claude betrayed the Leones, Misty has become significantly more menacing (especially after getting married to Joey) and is shown to fire guns very well.
 * Donald Love, Jr. (Will Janowitz) is Donald Love's 22-year-old son and the owner of Love Media. He is based on Donald Trump, Jr.
 * Frankie Leone (Finn Wolfhard) is Joey and Misty's 14-year-old son. He is set to be Don of the Leone family once Toni dies.
 * Luigi Goterelli (Joe Pantoliano) is the 67-year-old owner of Luigi's Sex Club 7, which is supposedly a nightclub but is in actuality a brothel in disguise.
 * Mickey Hamfists (Chris Tardio) is Luigi's 58-year-old bodyguard.
 * Felix "El Burro" Ramirez (Chris Phillips) is the 70-year-old Puerto Rican leader of the Diablos and a former porn star with a donkey fetish. He makes pornos (normal, gay, and donkey) for his studio, Ass in the Hole Productions, and is also a writer of adult literature, including Donkey Does Dallas and Muff and the Mule. In 1997, he posed as a Mexican-American homosexual and faked his death in Vice City.
 * Ilana "Ma" Cipriani (Sondra James) is Toni's 80-year-old, eternally unpleasable and overbearing mother who runs Momma's Ristorante. It's implied she loves her grandchildren more than Toni.
 * Phil Cassidy (Gary Busey) is the 66-year-old, one-armed owner of Phil’s Army Surplus.
 * "King" Courtney Wilson (Walter Mudu) is the 58-year-old leader of the Uptown Yardies. He is killed by Claude as revenge for using him in the mission "Long Live the King".
 * Elisabeth "Queen Lizzy" Campbell (Pam Grier) is King Courtney's 44-year-old wife.
 * Kyle "D-Ice" Veit (Walter Mudu) is the 46-year-old leader of the Red Jacks.
 * Yuka Kasen (Michelle Yeoh) is the 35-year-old shatei-gashira of the Yakuza. Her aunt Asuka was the leader of the Yakuza until her untimely death in 2001, and she became its head in 2003 on her 18th birthday (in the meantime, her sister Kagami was the leader).
 * Kagami Kasen (Kari Wahlgren) is Yuka's 39-year-old sister and the current Yakuza wakagashira. Wahlgren was cast as an in-joke to her Lucky Star character, Kagami Hiiragi.
 * Kemuri Kasen (Rio Sasaki) is Yuka's 15-year-old daughter. She is
 * Kaede Kasen (Fuku Suzuki) is Kemuri's 22-year-old cousin.
 * Izumi Nakamura (Wendee Lee) is Kagami's 38-year-old best friend. She is another in-joke to Lucky Star, as Lee is the voice of Konata Izumi, Kagami Hiiragi's best friend and later love interest.
 * Daisuki Nakamura (Sean Muramatsu) is Izumi's 41-year-old husband.
 * Akari Nakamura (Devon Aoki) is Daisuki and Izumi's 16-year-old daughter.
 * Allyson "Ally" Connors (Kathy Najimy) is the 56-year-old CEO of the Motlesor Channel, who is a parody of Christina Miller, Cyma Zarghami, and Brian Robbins. She seeks to pander to modern kids and has greenlit the successful series Impotent Rage, Here We Go! (a parody of the infamous Teen Titans Go!). She is killed by Josh in the mission "Ally the Above" for greenlighting a spinoff of Coralene Circleshorts (a SpongeBob SquarePants parody) called Summer Camp Circleshorts, which its deceased creator, Danny Jessup, was extremely against.
 * Roger "Kid" Forelli (Robert De Niro) is the 40-year-old Don of the Forelli Brothers, holding that role since 2006, when his older brother Franco Forelli was decapitated and killed in a violent shootout. Forelli and his entire remaining gang are killed by Toni Cipriani in the explosion of their car dealership in the Carraways during the mission "When the Kid Blows...", ending the Forelli Brothers once and for all.
 * Mullan "8-Ball" Levinsen II (Dule Hill) is 8-Ball's 28-year-old son. Like his deceased father, he is able to rig cars with bombs.
 * Darkel Harman (Bill Fiore, motion-capture performed by Gary Nelson) is a 61-year-old revolutionary street urchin who leads a group of similarly violent bums, and plans to bring down Liberty City's economy via acts of terrorism. He was a cut character from Grand Theft Auto III (all his missions were planned for that game), and the game was dedicated to his voice actor Bill Fiore's memory, as he died in 2014.
 * Curtis "Curtly" Macdonald (Curtis L. McClarin, motion-capture performed by Dule Hill) is the 31-year-old owner of the Supa Save! location in Portland. Like Darkel, Curtly was another cut character from Grand Theft Auto III. In addition, the game was dedicated to Curtis L. McClarin's memory, as he died in 2014.
 * Tom Novy (Tom Novy) is a 50-year-old German DJ who assigns Chris to take out hyperactive fans. Like Darkel and Curtly, Novy was another cut character from Grand Theft Auto III.
 * Carlos "Carl" Trejo (Renaud Sebbane) is the 43-year-old owner of the Bitch'n' Dog Food factory, and is an avid fan of the Liberty City Cocks. He also serves as a loan shark; players can borrow money from him, on the condition that they pay him back on time.

Brocklyn, Kings, Central Island, Brix, Law and Nixon, and New Guernsey (2D Universe Liberty City)

 * Robert "Bubba" Quincy (Travis Willingham) is a 45-year-old criminal-for-hire.
 * Divine West (Lupita Nyong'o)
 * Katie Andrews (Mila Kunis)
 * Oskar Kivlov (Michael J. Nelson)
 * Mikki Lee (Kristen Wiig)
 * Travis Reeves (Phil LaMarr)
 * Troy Robinson (Greg Johnson)
 * Ulrika Kivlov (Lisa Ortiz)
 * Lexi Wayne (Chloë Grace Moretz) is Margaret's estranged granddaughter. She openly applauds her grandmother's death.

Carcer City

 * James Earl Cash (Stephen Wilfong) is a man who posed as "J.R. East"
 * Mary-Ann Quinn (Dawn McGee) is a 45-year-old fitness freak who never got married. In a Strangers and Freak mission, Elise is disgusted by her misandry, accusing her of perpetuating the feminazi stereotype, and wastes little time putting a bullet in her head and dumping her body onto a passing coal train, with a news report on the radio telling of her body being found at a power plant during unloading and the plant employees allegedly engaging in necrophilia.

Obbesen

 * Leanne Wynn (Jennifer Morrison) is a 22-year-old criminal who works for the Petersen City Yakuza. She is an internet scammer who provides funding for the Yakuza.

Capital City

 * Donald Love (Alec Baldwin) is the 56-year-old cannibalistic and corrupt President of the United States, who was a Liberty City media mogul and mayoral candidate years before, and is the overall main antagonist of the game. He hires Chris to do work for him, such as killing his political opponents (both liberal and conservative) to ensure he wins his re-election campaign, defrauding and destroying liberal and/or left-leaning charities, slandering his remaining opponents by saying things like "He has six wives!" and "She kidnaps innocent people's dogs and eats them!", among other statements, blowing up a Mexican-American town in Matar to create a new Grand Penetrator, etc., threatening to frame him as a child rapist if he doesn't. It is heavily implied that Love is a pedophile who molests immigrant children personally. In the epilogue "Love Hurts", Love reveals that he was planning to turn the US into a fascist dictatorship known as the "First American Empire", with the ultimate goal to take over the world, kill everyone who isn't a straight, white, non-transgender Christian and sell their remains as food, send women back to the kitchen, and enslave the working class while he, his administration, and other wealthy "fat cats" prepare to take to the stars and do the same to alien races, treating non-rich citizens as objects rather than people, and also reveals that he orchestrated C.R.A.S.H.'s resurrection, hoping to use it to serve his purpose, and, along with Vladimir, ordered Walt's wife killed under the pretense that she was killed by a gang member; Jillian leaves him upon this revelation, taking Tiffany and Crispin with her. He and his entire remaining administration are killed by Josh and Elise in a violent shootout. Moreso than in previous games, Love is a very unflattering caricature of Donald Trump in terms of personality (though he still retained his III-era appearance, albeit much older), right down to being portrayed by Alec Baldwin (who plays Trump on Saturday Night Live, though Baldwin uses his normal voice) which sparked massive backlash from conservatives.
 * Jillian Love (Maisie Williams) is the 31-year-old First Lady. It's implied throughout the storyline that her husband abuses her and forces her to go along with his agenda under threat of rape, which is confirmed in "Love Hurts". She is based on Melania Trump.
 * Crispin Love (Julian Edwards) is Donald and Jillian's eleven-year-old son who has a tendency to wear suits every day, and is very soft-spoken (to the point of having only one line, being "Come on, let's go. Leave this schmuck of a father to his fantasies" after Jillian leaves Donald). He is based on Barron Trump.
 * Tiffany Love (Genevieve Hannelius) is Crispin's bratty, 17-year-old step-sister and an aspiring model. She is based on Tiffany Trump.
 * Charles "Chuck" Dollar (Michael Douglas) is the 59-year-old Vice President, and is also a conservative. He is utterly disgusted with Love, but stays with him because he has Stockholm syndrome. He ends up betraying Love in the epilogue by taking the last shot, and becomes the new president after Love is killed, promising to actually make America great for everyone, and not just rich whites. He is based on Mike Pence.
 * Donner Gill (John Goodman) is Love's 69-year-old lawyer and the former Mayor of Liberty City. He is based on Rudy Giuliani.
 * Mike Toreno (James Woods) is a 72-year-old government agent turned head of the IAA. He disapproves of some of the IAA's more heavy-handed tactics, and becomes one of the Walton twins' most valuable allies in waging a shadow war against Love.
 * Jay Cook (Tom Wilson) is the 60-year-old head of the FIB.

Alderney

 * Jonathan "Johnny" Klebitz (Scott Hill) is the 45-year-old founder of the New Lost MC and President of its Alderney chapter. He survived Trevor stomping his head in because it never happened in the first place; Trevor was actually stomping the ground, having a psychotic episode after learning Michael was alive, but Ron and Wade didn't want to say anything for their own safety. Johnny seeks to find and kill Trevor for destroying the old Lost. He is playable in a few missions.
 * Jonathan "Johnny" Vincent (Rocco Rosanio) is the Vice President of the New Lost MC.

Bullworth

 * James "Jimmy" Hopkins (Gerry Rosenthal) is the 28-year-old mayor of Bullworth. In 2006, he uncovered the many problems of Bullworth Academy, and successfully changed the school for the better. He is playable in the mission "Lockdown", being the only playable character who can't use weapons because he chooses not to.
 * Peter "Pete" Kowalski (Matt Bush) is the 27-year-old Headmaster of Bullworth Academy. He became the head after Dr. Crabblesnitch retired in 2017, having been the head boy after Gary got expelled.
 * Gary Smith (Peter Vack) is a 29-year-old SPANKed-up street criminal who assigns Elise to do some work for him. He is killed in the mission "Lockdown" when he instigates a mass shooting at Bullworth Academy, and is thrown off of the school building by Jimmy again, this time fatally.
 * Zoe Taylor-Hopkins (Molly Fox) is Jimmy's wife.
 * Pedro De La Hoya (Daniel Tay) is the 27-year-old Deputy Mayor of Bullworth.
 * Karen Johnson (Cai Oglesby) is Pedro's wife.
 * Seth Kolbe (Tom Vergow) is a former prefect. He is the coach of the Bullworth Bulls.
 * Ralph Crabblesnitch (Ralph Gunderman) is the former Headmaster of Bullworth Academy.
 * Earnest Jones (Jesse Tendler) is a teacher at Bullworth Academy.
 * Elise Peabody (Flo Salant) is the hall monitor at the Girls' Dorm.
 * Algernon "Algie" Papadopoulos (Brett Tabisel) is a 28-year-old teacher at Bullworth Academy.
 * Beatrice Trudeau (Caitlin Greer) is the nurse of Bullworth Academy.
 * Derby Harrington (John LaVelle) is the rich and snooty owner of the Harrington Oil Corporation. He is a noted supporter of Donald Love.
 * Christy Martin (Maine Anders) is the 29-year-old creator of T.M.I. (a parody of TMZ).
 * Angie Ng (Sue Jean Kim) is Christy's 28-year-old best friend and the owner of a bunny sanctuary.
 * Sheldon Thompson (John Magaro) is
 * Robert "Bob" Bradley (Tom Vergow) is a 29-year-old homosexual football player.
 * Tad Spencer (Baron Vaughn) is the CEO of Spencer Shipping.
 * Clinton "Clint" Albert (a.k.a. Henry Jefferson) (Justin Mortelliti) is a wanted criminal.
 * Ted Thompson (Alex Cendese) is a professional football player. He plays for the Bullworth Commandos.
 * Russell Northrop (Cody Melton) is Jimmy's personal bodyguard.
 * Daisy Adams (Kiernan Shipka) is a 21-year-old New Coventry graduate. She is playable in a few missions.
 * Cheyenne Matthews (Abigail Breslin) is Daisy's 23-year-old best friend.

Houser

 * Edward Olsen (Norm Macdonald) is a 51-year-old propane salesman affiliated with the Fallons. Macdonald was cast as Olsen based on his impersonation of Burt Reynolds in the Celebrity Jeopardy! skits on Saturday Night Live; Tommy remarks that Olsen reminds him of "some rug-wearing prick I once knew in my past".
 * Karl Fallon (Norman Lloyd) is the 85-year-old Don of the Fallon Crime Family. He is typically polite and civil, but will get enraged when provoked. He is killed under Kurt Adams' orders during the mission "Karl Retires".
 * Raymond "Junior" Fallon (Amos Crawley) is Karl's 48-year-old son and eventual successor, and the family Underboss. After "Karl Retires", Junior becomes the Don.
 * Renee Jacobs (Dakota Fanning) is the 30-year-old crackpot founder and leader of the equally-crackpot PAAC (People Against Animal Cruelty).
 * Kurt Adams (Clancy Brown) is the 49-year-old, corrupt Mayor of Houser.
 * Fred Peters (Jack Quaid) is a 19-year-old street criminal.

Leston (a.k.a. Anywhere City)

 * Cinco Carbine (Joseph D. Kucan) is the leader of the Zaibatsu Corporation. He is the son of Uno Carbine, who was killed in 1999. He is killed by Claude during the mission "Carb's Last Call".
 * Bob Welsh (Randall Park) is the co-leader of the Zaibatsu Corporation, and the brother of Trey Welsh, who was killed in 1999. He and several Zaibatsu guards are killed by Claude during the mission "Instant Justice - Just Add Blood".
 * Calligari Hisashi (Alex Landi)
 * Candace “Candy” Robertson (Keke Palmer)
 * Edward “Eddie” Skinner (Dwayne Johnson)
 * Gretchen Austin (Debi Mazar)
 * Paulo López (Gael García Bernal)
 * Ruben Conner (Anthony Anderson)

Songs

 * "Gangster Friday/Grand Theft Auto (Joyride)" by Craig Conner a.k.a. Da Shootaz (1997; Flash FM)
 * "Billie Jean" by Michael Jackson (1983; Vice City FM)
 * "Gangsta's Paradise" by Coolio (1995; Vice City FM)

"Good Old" Avery

 * Avery Carrington (Burt Reynolds) was a real-estate mogul. He would do anything to get prime real estate, like starting gang wars to lower property values. He was killed by Toni Cipriani under the orders of his old apprentice, Donald Love, who proceeded to eat his corpse, in 1998. The game was dedicated to Reynolds, who died in 2018, but had completed all of his scenes.

Sonny Forelli: A True Story

 * Stefano "Sonny" Forelli (Tom Sizemore) was the second Don of the Forelli Crime Family, taking over the position in 1965 after his father was killed in a gang war, becoming the youngest Don in Mafia history at the age of 19. He was killed by Tommy Vercetti in 1986 in an attempt to expand his family to Vice City.
 * Angelo "Lucky" Forelli (Dominic Chianese) was Sonny's father, who was born in 1903. He was the original Don of the Forelli Crime Family from its inception in 1929 until his 1965 death.
 * Giuseppe Forelli (Steve Buscemi) was Sonny's older brother, who was born in 1934. He and Sonny clashed on who should run the Forellis until Sonny ordered several henchmen to kill him in 1975.
 * Marco Forelli (Joseph Badalucco Jr.) was Sonny's younger brother, who was born in 1952. He founded Marco's Bistro in 1980, and was the third Don of the Forelli Crime Family from 1986 until his death in a shootout in 1992.
 * Franco Forelli (Tony Darrow) was Sonny's eldest son, who was born in 1970. He was the fourth Don of the Forelli Crime Family from 1992 until his death from being stuffed in the trunk of his own car by some Leone members and being crushed in it in 2006.
 * Michael "Lips" Forelli (Joe Mantegna) was Franco's younger brother, who was born in 1974. He was the Underboss of the Forelli Crime Family from 1992 until his death in 2001. His favorite hangout was Marco's Bistro, where he had all the food he could eat, giving him his "Lips" nickname. He was killed by Claude Speed under the orders of Joey Leone in 2001 when Speed had 8-Ball put a bomb in Forelli's car, causing it to explode with him in it.

Leone

 * Salvatore Leone (younger version: Richard Portnow; older version: Frank Vincent) was the second Don of the Leone Crime Family from 1985 until his death in 2001 at 66. Unlike in the games, the movie downplays his severe paranoia and portrays him as an unambiguous hero and family man, a jab at how the 2018 film Gotti treated real-life mob boss John Gotti. This game lists Frank Vincent (who died in 2017) as one of the many dedications.
 * Eufrasio Leone (Bruce MacVittie) was the first Don of the Leone Crime Family from its 1939 founding until being forced to leave the family in a power struggle in 1985.
 * Antonio "Toni" Cipriani (Danny Mastrogiorgio) was Salvatore's right-hand man. He is portrayed in a way that favored the real Cipriani.